Assessment of Querectin Influence on Multiple Physiological, Biochemical and Immunological Parameters in Diabetic Rats

Diabetes is a worldwide disease threatens a large number of the human population due to their complication which extended to almost all body organs. Recently querectin were studied to their pharmaceutical activities.

Therefore this paper studied the effect of querectin on multiple physiological, biochemical and immunological markers for diabetic rats supplemented with querectin 150 m/k orally for 30 days.

The result revealed that lipid profile improved in treated rats in-compared to untreated groups as cholesterol result was 176±3.09 mg/dl versus 210±5.2 mg/dl in the untreated group, triglyceride 150.3±2.85 mg/dl versus 176±4.30 mg/dl, high density lipoprotein result was 37.42±2.9 mg/dl versus 24.43±3.2 mg/dl, low density lipoprotein 109.59±6.85 mg/dl versus 151.29±5.70 mg/dl and very low density lipoprotein (30.45±2.90 versus 35.20±3.52) mg/dl in P value ≤0.01. In addition, glucose level was gradually reduced in treated group against non-treated one (200.43±1.96, 320±2.85) mg/dl. Urea and creatinine level was restored in quarectin treated rats (29.50±2.43, 0.96±0.06) mg/dl respectively in compared to diabetic untreated rats (37.54±3.53, 1.6±0.05) mg/dl. Immunological parameters including TNF-α, IL-1, IL-6 and C-reactive protein (CRP) showed a significant reduction in comparison to untreated rats (2.48±0.39, 4.70±1.22) for TNF-α, (4.38±1.59, 7.69±1.32) for IL-1, (3.24±0.12, 5.05±1.42) and (4.60±0.53, 5.05±0.54) for CRP. Similar results was shown in lactate dehydrogenase (157.54±3.65, 17.54±3.32) for treated and non treated rats respectively, anti-oxidant parameters were measured and te results were catalase significantly restored in treated group (10.30±2.76, 13.70±2.63), super oxide dismutase (7.13±2.67, 9.94±2.94) and malondialhdeyde (2.90±0.39, 4.89±0.48) in a P value ≤0.05.