Asian Journal of Dairy and Food Research
SCOPUS
  • Year: 2025
  • Volume: 44
  • Issue: spl

Estimation of Coagulation FXlll and FXIII A1 Serum Levels in Iraqi Individuals Affected with FXIII Deficiency

  • Author:
  • Murtadha A. Alshami1,2,*, Asmaa Mohammed1
  • Total Page Count: 7
  • Page Number: 122 to 128

1Department of Biotechnology, College of Science/University of Baghdad, Baghdad, Iraq

2College of Biotechnology, Al-Nahrain University, Baghdad, Iraq

*Corresponding Author: Murtadha A. Alshami, Department of Biotechnology, College of Science/University of Baghdad, Baghdad, Iraq, Email: alshami.mortadha@yahoo.com

Online Published on 10 March, 2026.

Abstract

The uncommon bleeding condition known as factor XIII (FXIII) deficiency can cause symptoms that range from cerebral hemorrhage to delayed umbilical cord separation. When activated, FXIII is essential for maintaining clot stability and promoting fibrin polymer cross-linking, which guarantees efficient hemostasis. A genetic or acquired FXIII deficiency can cause aberrant bleeding tendencies and decreased clot stability. In Iraq, FXIIID is a common rare bleeding disorder.

Samples included in this study were families that have some affected individuals with coagulation factor XIII deficiency and healthy persons that are unaffected by any bleeding disorder, with different ages and from different areas of Baghdad- Iraq, to determine FXIII and FXIII-A1 serum levels by Elisa among different genotype individual affected with FXIII deficiency with hime families in addition to recounting some of the coagulation tests (PT, PTT, INR and platelete account).

The results revealed a statistically significant difference in platelet counts between the two groups (P<0.01), with affected individuals exhibiting a significantly higher mean platelet count (240.20 *109/L±70.21) compared to the control group (201.05*109/L±27.64). Affected individuals exhibited a significantly shorter PTT (31.60 s±4.36) compared to the control group (33.88 s±2.74) with a P-value (P=0.04), while their INR values were significantly higher (1.12±0.20) compared to controls (0.99±0.12) (P=0.02). No significant difference was observed in PT values between the two groups. The mean of FXIII-A1 was (2.38, 2.86 and 7.54) ng/ml and the mean of FXIII in total was (212.51, 222.81 and 230.38) ng/ml, respectively; homozygote, heterozygote and control group. In a comparison of the difference in the level of FXIII and FXIII A1 between the affected and the control, the rate decrease in the level of FXIII as a whole is approximately 36% below the normal level, while the rate decrease in FXIII A1 is approximately 69% below the normal level.

Keywords

Coagulation factors, ELISA, FXIII A, FXIII deficiency, FXIII