1Post Graduate, Dept.of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054, India
2Professor, Dept.of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054, India
3Assistant Professor, Dept.of Pharmacognosy, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054, India
*Contact Author E-mail: anitamurali.pg.ph@msruas.ac.in
Online published on 18 January, 2019.
The present study was conducted to evaluate the anti-hypertensive activity and vasorelaxant potential of alcohol extract of Mitragyna parvifolia root. Hypertension was induced by uninephrotectomy followed by the administration of 1%w/v sodium chloride solution with drinking water and s.c injection of desoxy corticosterone acetate (20 mg/kg). The alcohol extract of M. parvifolia root was administered at doses 200 and 400 mg/kg. Systolic blood pressure and heart rate were measured along with serum levels of TC and TG. Vasorelaxation property of the extract was evaluated on isolated rat thoracic aorta against calcium chloride induced contractions. Test extract at dose 400 mg/kg was found to be effective in controlling blood pressure. The extract of M. parvifolia root at concentrations 1 and 10 mg/ml was found to be effective in countering CaCl2 induced contractions on the isolated tissue. The study thus concludes the anti-hypertensive and vasorelaxation potentials of alcohol extract of M. parvifolia root.
Mitragyna Parvifolia, Anti-Hypertensive Activity, DOCA-Salt, Vasorelaxation, Rat Aorta
