1Ex Post Graduate, Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
2Assistant Professor, Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
3Head and Professor, Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
*Corresponding author Email: sharoncaroline.ps.ph@msruas.ac.in
Online published on 18 January, 2019.
The aim of the study was to develop a taste masked oro dispersible tablet of Promethazine Hydrochloride.
Taste masking was achieved by complexation with β-cyclodextrin. The tablets were formulated using cross carmellose sodium as superdisintegrant and camphor, menthol, ammonium bicarbonate as sublimating agent.
The vaporization of the sublimating agents from the tablets resulted in creation in a porous surface morphology as seen in the SEM. Satisfactory results were obtained when the formulations subjected to different pre-compression tests like Angle of Repose, Hausner's Ratio, Carr's Index, Bulkiness and post compression tests like Hardness, Thickness, Uniformity of Weight, Friability, Drug Content, Wetting Time, Water Absorption Ratio, Disintegration Time and Dispersion study and In vitro dissolution study showed a drug release of 90.15% to 95.82% within 30 minutes. Studies for taste analysis was carried out using E-tongue and the results showed satisfactory taste masking for all the tablet formulations.
Taste masked oro dispersible tablets of promethazine HCl were successfully prepared with good preformulation and post compression results.
Promethazine HCl, Oro Dispersible Tablets, SuperDisintegrant, Sublimation, antiemetic
