1Assistant Professor, Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
2Professor, Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
3Professor and Head Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
*Corresponding Author E-mail: mohammadazamthulla@gmail.com
Online published on 24 January, 2020.
The antiulcerogenic effects of the aqueous extract of Jathropa curcas Linn. on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa has been investigated.
Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides, which were elevated highly in rats with acute gastric mucosal injury, was taken as an index of oxidative stress. The activities of antioxidant defense enzymes were also decreased considerably by oral gastric administration of aspirin.
The decreased levels of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with Jathropa curcas Linn. extract when compared to the ulcer induced rats. The results indicate that Jathropa curcas Linn. extract may exert its gastro protective effect by a free radical scavenging action.
Our observations suggest that Jathropa curcas Linn. extract may have considerable therapeutic potential in the treatment of gastric diseases.
Aspirin, Antioxidant Enzymes, Jathropa curcas Linn, Ulcer Healing
