1Post Graduate Students, Head DDDC, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
2Assistant Professor, Head DDDC, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
3Associate Professor, Head DDDC, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
4Head and Professor, Department of Pharmaceutics, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Gnanagangothri Campus, New BEL Road, M S R Nagar, Bangalore, Karnataka, India-560 054
Online published on 24 January, 2020.
The present work emphasises on development of Directly Compressible (DC) calcium carbonate based pharmaceutical excipients to aid in faster the manufacturing process.
DC granules were prepared using different ratios of Calcium Carbonate (CC) and diluents such as dextrose and mannitol in varying ratio 60: 40, 70: 30, 80: 20 and 90: 10 without and with Poly Vinyl Pyrolidone (PVP) as binder in concentration of 0.5 and 5%. Prepared granules were evaluated for pre-compression parameters. Domperidone, an anti-emetics agent was chosen as a model drug. Domperidone was blended with these directly compressible excipients and compressed into tablets. Prepared tablets were subjected for weight variation studies, hardness, friability and assay, in-vitro disintegration and in-vitro dissolution studies.
Prepared formulations showed better flow properties when compared to Calcium Carbonate alone. Tablets were subjected to post compression evaluations and the results shown were acceptable. The formulations showed 80% drug release within 30mins.
Thus DC granules for direct compression method was formulated successfully which can be used for routine production with lesser manufacturing unit operation process, cost and time.
Calcium Carbonate, Dextrose, Directly Compressible Granules, Pharmaceutical Aid
