1Senior Lecturer, Department of Conservative Dentistry and Endodontics, I. T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India
2Professor and Head, Department of Conservative Dentistry and Endodontics, I. T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India
3 Consultant Endodontist, Department of Conservative Dentistry and Endodontics, I. T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India
4Professor, Department of Conservative Dentistry and Endodontics, I. T.S Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, Uttar Pradesh, India
*Address for Correspondence: Shubhra Malik, Senior Lecturer, Department of Conservative Dentistry and Endodontics, I. T.S Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, INDIA E-mail: dr.shubhramalik@gmail.com
Online published on 20 September, 2016.
The aim of the study was to evaluate the sustained release effect of 2% chlorhexidine and its combination with 2% chitosan, in vitro.
The sustained release effect of chlorhexidine and its combination with chitosan was determined using a UV spectrophotometer.
UV spectrophotometer analysis for the sustained release of chlorhexidine showed that almost 100% of chlorhexidine was released within 4 hours. However when chlorhexidine was combined with chitosan, only 59% of chlorhexidine release was observed even at 24 hours.
The percentage drug release of chlorhexidine was almost half when used in combination with chitosan, thus indicating the sustained release property of chitosan.
Chitosan, Chlorhexidine, Sustained Release Effect
