Department of Zoology, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India.
The present study aimed to investigate the alterations in selected hematological parameters (total erythrocyte count, total leucocyte count, hemoglobin concentration, packed cell volume, erythrocyte sedimentation rate and red cell indices(MCV, MCH, MCHC) of wistar albino rats after short term (80 ppm, 1h/d for 28 days) exposure to SO2 gas and protective effect of vitamin E (2.5mg/rat) and C (5mg/rat) individually and in combination. The results of the present study imply that hematological parameters altered after SO2 gas inhalation and lead to reduction in TEC, Hb.Conc., PCV and red cell indices, while elevation in TLC and ESR. However, SO2 induced hematological alterations modulated after supplementation of vitamin E and C individually and in combination due to antioxidant defense mechanism against toxic action of SO2 inhalation. The findings of the present study exhibit that the supplementation of vitamin E and C in combination have more potential to mitigate SO2 induced hematological alterations in albino rats than the supplementation of vitamin E and C individually.
SO2 gas, Hematological alterations, Albino rats, Vitamin E and C
