Possible occurrence of apoptosis in Endosulfan induced testicular toxicity in mice

Endosulfan an organochlorine pesticide is known to cause deleterious effect on the reproductive organs of humans. In the present investigation, Endosulfan at 3.0 mg/kg b.w was administered to Swiss albino mice for 4 weeks. Animals were sacrificed and their testicular tissues were fixed for Transmission Electron microscopic study. The Electron microscopic study reveals the degenerative changes in testis at subcellular level. The plasma membrane, nuclear membrane, chromatin material and mitochondria, etc. show degenerative changes. It was concluded that Endosulfan causes damage to spermatozoa in Swiss albino mice.