Combined Effect of Tamarindus indica and Emblica officinalis on enzyme profile and lipid profile after fluoride intoxication in albino rats

The present investigation was carried out to evaluate the combined effect of Tamarindus indica and Emblica officinalis on serum enzyme profile and lipid profile after fluoride intoxication in albino rats. Both these medicinal plants have been used as a valuable ingredient of various medicines in India. Three groups of ten adult male albino rats were administered 14.29 mg/L fluoride drinking water (collected from the fluoride zone in Agra region) for 30, 45 and 60 days and another three groups of ten rats were treated first with fluoride water in the same way as mentioned above and then treated with combined T. indica (10gm/Kg body weight) and E. officinalis (500 mg/Kg body weight) fruit extract (mixed in ratio of 1:2) orally for 15, 30 and 45 days, respectively. Results showed a very highly significant (p<0.001) increase in serum AST, highly significant (p<0.01) in ALT and non-significant (p>0.05) increase in LDH after fluoride water intoxication; while a very highly significant (p<0.001) decrease in serum AST, highly significant (p<0.01) decrease in ALT and nonsignificant (p>0.05) decrease in LDH after combined T. indica and E. officinalis treatment, respectively. There were observed highly significant (p<0.01) increase in serum total cholesterol, LDL, VLDL, very highly significant (p<0.001) increase in TG and a very highly significant (p<0.001) decrease in HDL after fluoride intoxication; while a very highly significant (p<0.001) decrease in serum total cholesterol, LDL, VLDL, TG and a very highly significant (p<0.001) increase in HDL after combined T. indica and E. officinalis treatment, respectively. T. indica reduces the serum fluoride concentration through chelation bio-mechanism and provides nutrients; while E. officinalis acts as a strong antioxidant. We concluded that T. indica and E. officinalis have compensated the fluoride toxicity that affects the body metabolism.