Sulphur dioxide gas induced histopathological changes in liver of albino rat

The Present study is designed to evaluate the effects of short-term SO₂ inhalation (28 days) on rat liver. The histopathological changes in rat liver after 28 days SO₂ exposure (80 ppm/hr/day) include moderate hepatocyte necrosis, degeneration of hepatocyte, centrilobular necrosis, ballooning degeneration and cellular debris. SO₂ inhalation causes marked elevation in Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT) and Serum alkaline phosphatase (SALKP) activity in comparison to control rats. There is a significant reduction in body weight, food consumption and liver weight of albino rat after inhalation of toxic gas.