Challenges in estimation of post mortem interval from vitreous potassium concentration in global perspective: A systematic review

Postmortem interval as an essential component of death investigation needs to be precisely estimated scientifically as far as practicable. In decomposed bodies, vitreous humour potassium concentration holds scientific merit as they resist early bacterial putrefaction. However, the quantitative estimation of ion depends on several factors, such as climatic, seasonal, storage conditions apart from biological age and hidden pathological condition of the deceased concerned. Thus equations formulated in a particular climatic condition may not be validated with other. Some of the studies generated regression equations based on their regional climatic considerations, but they highly vary with other studies performed across the geographic barrier. Global studies suggested immediate freezing of samples below -20°C to maintain its quality for forensic analysis. Samples should not be exposed to light and temperature. The immediate challenges in the field are explored and outlined comprehensively and possible solutions to the feasible context are recommended.