Antifertility studies of Phologacanthus Thyrsiflorus nees: A potential ethno-medicinal plant of north east India

Currently, there are number of hormonal contraceptives available in the market but they have various side effects. Keeping these views in mind, the present investigation deals with the antifertility evaluation of some traditionally using ethnomedicinal plants. Phlogacanthus thyrsiflorus Nees (Family Acanthaceae) leaves extract was investigated for anti-implantation, on successive stages of embryogenesis, at the dose of 150 and 300 mg/kg body weight. The post-treatment results showed a significant inhibition site at a dose of 300 mg/kg. The observations recorded showing no change in ovulation, no change in weight of ovaries and no change in cholesterol level in the anti-ovulatory activity. Further, the acute oral toxicity test was also carried out according to the OECD guidelines; no toxic reaction or mortality on rats were observed.

Therefore, findings of the present investigations prompt us to do the detailed histological, pre-clinical as well as clinical investigation; so that, the antifertility activity of the P. thyrsiflorus can be explored pharmaceutically as potential anti-implantation and abortifacient agent.