Journal of Immunology and Immunopathology
  • Year: 2014
  • Volume: 16
  • Issue: 1and2

Hypersensitivity Reactions: The Fulcrum of Immunopathology

  • Author:
  • Manoranjan Rout1, Suvendu Kumar Behera2,*, Ranjan Kumar Mohanta3
  • Total Page Count: 13
  • Published Online: Jan 1, 2014
  • Page Number: 20 to 32

1ICAR-Project Directorate on Foot and Mouth Disease, IVRI Campus, Mukteswar, Nainital-263138, Uttarakhand, India

2Department of Veterinary Medicine, College of Veterinary Sciences & Animal Husbandry, Selesih-796014, Mizoram, India

3(Animal Science), Krishi Vigyan Kendra, Central Rice Research Institute, Cuttack-756003, Odisha, India

*Corresponding author email id: drsuvendu.kumar@gmail.com

Abstract

The environment is used as a broad umbrella term for all sources of allergens which may cause allergic hypersensitive reaction of the immune system of humans and animals. Hypersensitivity is the name given to a state in which an immune response damages the body’s own tissues. It is a process of reactions of antigen with antibody or sensitised lymphocytes that are harmful to the host. When an adaptive immune response occurs in an exaggerated or inappropriate form causing tissue damage, the term ‘hypersensitivity’ is applied. There are four or five types of hypersensitivity that are often described. Research has focused on understanding each hypersensitivity reaction to ensure appropriate therapeutic recommendations. This article elucidates the details of different types of hypersensitivities and different methods of detection.

Keywords

Adaptive immune response, Allergens, Eosinophils, Mechanism, Lymphocytes, Hypersensitivity, Immune system, Tissue damage