1Animal Husbandry Department, Govt. of J & K, Jammu, Jammu and Kashmir, India
2Division of Veterinary Pharmacology and Toxicology, SKUAST-J, Jammu, Jammu and Kashmir, India
3Department of Livestock Products Technology, Arawali Veterinary College (Affiliated with RAJUVAS, Bikaner), Jaipur Road, Bajor, Dist. Sikar, Rajasthan, India
4Department of Veterinary Microbiology, Arawali Veterinary College (Affiliated with RAJUVAS, Bikaner), Jaipur Road, Bajor, Dist. Sikar, Rajasthan, India
5Division of Veterinary Public Health, SKUAST-K, Srinagar, Jammu and Kashmir, India
*Corresponding author email id: ganguly38@gmail.com
The present study was designed to evaluate the effects of chlorpyrifos (CPF), lead acetate, vitamin C alone and in combination on the activity of cholinesterase in Wistar rats. Materials and Methods: Rats of 150–200 g body weight were divided into eight groups of six animals each and were subjected to various treatment regimes for 98 days. Group I served as control receiving corn oil, group II received CPF at 5.5 mg/kg in corn oil, group III received lead acetate at 100 ppm in water, whereas animals in group IV received a combination of CPF at 5.5 mg/kg in corn oil and lead acetate at 100 ppm in water. Group V received vitamin C at 100 mg/kg b.wt in water, group VI received a combination of CPF at 5.5 mg/kg and vitamin C at 100 mg/kg, group VII received lead acetate at 100 ppm in water and vitamin C at 100 mg/kg and group VIII received CPF at 5.5 mg/kg, lead acetate at 100 ppm in water and vitamin C at 100 mg/kg. Results and Discussion: From the results, it was observed that activities of erythrocyte, plasma and tissue cholinesterase decreased significantly in both CPF and lead-treated rats. Conclusion: Activities of cholinesterases induced by exposure to CPF and lead were mitigated by treatment with vitamin C.
Chlorpyrifos, Lead acetate, Vitamin C, Cholinesterase
