1R&D Laboratory, Indian Herbs Research & Supply Co. Ltd., Saharanpur - 247 001, India.
2Department of Pharmacology, College of Veterinary Sciences, HPKVV, Palampur, (H.P.).
An important factor for success of antimicrobial chemotherapy is the host immune status. Experiments were, therefore, conducted to assess the adjuvant effect of Immu-21. In first experiment, 48 mice divided into four groups were infected with Staphylococcus aureus. These mice were treated either with tetracycline or Immu-21 or both to observe the effect of Immu-21 on the efficacy of antimicrobial chemotherapy. In second experiment, the effect of Immu-21 against caecal ligation induced abdominal infection was studied in 48 rats divided into four groups. The rats were treated either with antibiotics (metronidazole+gentamicin) or with Immu-21 or both.
In comparison to antibiotic alone treated group, combined treatment with Immu-21 reduced the mortality to 5 (41.66%) as compared to 8 (66.66%) in experiment I and to 2 (16.66%) as compared to 5 (41.66%) in experiment II. In both the experiments, 100 percent mortality was observed in control groups. The results indicate that Immu-21 enhances the therapeutic success rate of both bacteriostatic and bactericidal antibiotics by optimising host immune status. Looking to declining success of antibiotics and increasing bacterial resistance, Immu-21 can be used as an adjuvant to antimicrobial therapy for better control of infections.
Immu-21, Immunomodulation, Mice, Rats
