Immunopathology of Classical Swine Fever

Classical swine fever causes high impact on porcine health and in the nascent developing pig industry. The virus infection of pigs causes severe to asymptomatic disease courses depending on involvement of strain of the virus. CSF virus is having affinity to immune associated cells particularly macrophages and dendritic cells. In this review biology of the CSF virus is discussed in details. Again, various clinical and pathological alterations recorded in field studies are tried to explain the underlying immune-patho-mechanisms through various concepts put forwarded by workers around the globe. Various studies indicated that the immune mediated pathological mechanisms are involved at cellular level rather than the damage directly cause by the virus. Role of interferons in immunopathology of CSFV is significant. Type of interferon markedly distinguishes between CSFV infection and vaccination. The review concludes with a remark that despite the knowledge available many aspects of classical swine fever immunopathogenesis are still unexplored.