Human Immune System and Cancer-A Brief Review on the Elements of Tumour Microenvironment

According to World Health Organization, cancer is among the leading causes of mortality and morbidity worldwide. The cancer burden is increasing at an alarming rate owing to which there is a grave necessity for an ideal treatment intended to deal with this killer disease as conventional cancer therapies are incapable of exterminating remnant or metastatic tumour cells that are defiant to therapy. Consequently, it is obligatory to reinforce new methods for treating such cancer cells to improve the clinical outcome of cancer patients. Mammalian immune system cells like cytotoxic T cells, natural killer cells and gamma delta T cells are crucial components of immune system. All these cells synergistically play an important role in immunotherapy. In this review, we have emphasised on the roles of important immune cells on tumour cells, tumour microenvironment and their clinical implications.