Importance of Dietary Nucleotides and its Impact on Immunomodulation: A Review

Prakash S, Palod J, Naik HS and Shamsudeen P (2020). Importance of Dietary Nucleotides and its Impact on Immunomodulation: A Review. Journal of Immunology Immunopathology, 22(1): 10-18.

Genetic selection and Intensive system of husbandry practices pave the way for high animal protein requirements by increasing the animal’s productive potential in the past decades. To counterbalance the production traits, immune parameters are unacquainted. Targeting the nutrition of animals is the elementary way to optimize both production and immune performance. Nucleotides emanate as potential immune stimulants, since biosynthetic pathways are inefficient to supply huge demand for additional nucleotides requirement for immune cell proliferation during the indispensable stress periods. Hence, nucleotides are described as ‘conditionally essential’ elements. Numerous animal experiments divulge that inclusion of nucleotide in diet showed multiple advantages, such as increased disease resistance, acceleration of antibodies production, stimulating the neutrophils and macrophages (leukocytes) production, and T cells activation which are reviewed in this article in brief.