Journal of Immunology and Immunopathology

This research studied ultrasonographic (US) changes in lens opacity and thickness of the lens, aqueous humour, and anterior chamber post-dispensing CoQ10 eye drops in a rabbit model of cataracts in vivo. Twelve adult and healthy New Zealand white rabbits with healthy eyes and other eye structures and normal corona shape and lens size underwent US. The rabbits were split into control and experimental groups. Control rabbits received artificial tear (AT) drops, and those in the experimental group received CoQ10 eye drops 3* a day, each shot containing two drops. CoQ10 eye drops were prepared by a pharmacologist by dissolving 300 mg of soluble CoQ10 in a sufficient amount of distilled water to obtain a final 0.3% w/v solution. All the experimental rabbits were injected with Na selenite and CoQ10 eye drops from day one of the study. Next, the US machine SONOSCAPE was used to measure and evaluate lens opacity and thickness of the lens, aqueous humour, and anterior chamber every two days. The obtained data were then analysed using IBM SPSS Statistics. The mean anterior chamber thickness in CoQ10-receiving rabbits was markedly higher than the controls on the 17th day. However, the corresponding value was not significantly different between the two groups on the other days of the study. In the first measurement, the mean aqueous humour thickness in the CoQ10 group was markedly lower than in the AT group. Contrarily, the corresponding value in the CoQ10 group was significantly higher than that in the AT group on the 17th day of the study. However, there was no marked difference in the mean aqueous humour thickness between the two groups on the other days of the study. The mean lens thickness in the first measurement and on days 3, 7, 10, and 14 in the CoQ10 group was markedly higher than the AT group. However, the mean lens thickness was not significantly different between the two groups on the other days of the study.