Antigen presenting potential of buffalo monocytes: Presentation of foot and mouth disease virus antigens

The work presented in this paper describes the antigen presenting potential of monocytes obtained from naturally foot and mouth disease virus (FMDV) infected butTalo calves, and buffalo and cattle calves vaccinated with polyvalent oil adjuvanted FMD vaccine. In FMD infected calves, significant antigen presentation by primed monocytes to naive peripheral blood mononuclear cells (FBMe) was observed against type A22 as well as type O. However, incorporation of tritiated thymidine was significantly higher in Type A22 stimulated cultures compared to those recorded in type O stimulated cultures. In vaccinated buffalo and cattle calves significant antigen presentation of FMDV type O and A22 by monocytes to naive PBMC was recorded. These findings strongly suggest the role of monocytes in the induction of immune response in both infected as well as vaccinated calves against FMDV.