Journal of Immunology and Immunopathology
  • Year: 2001
  • Volume: 3
  • Issue: 2

Effect of experimental zinc deficiency on immunological responses in foot and mouth disease vaccinated Guinea pigs

  • Author:
  • R. Kumar1, S. K. Munjal1, R. Sharma2, P.C. Verma1
  • Total Page Count: 8
  • Page Number: 45 to 52

1Department of Veterinary Pathology, CCS Haryana Agricultural University, Hisar-125004, (Haryana).

2Department of Veterinary Microbiology, CCS Haryana Agricultural University, Hisar-125004, (Haryana).

Abstract

Guinea pigs given zinc deficient or zinc adequate diets, containing 1.02 or 52 mg Zn/kg diet, respectively, were vaccinated with FMD ‘O’ type monovalent vaccine on 2nd week and challenged with FMD ‘O’ type 100000 TCID50 virus on 5th week. Cellular and humoral immune responses to FMD vaccination were assessed by delayed type hypersensitivity (DTH) and serum neutralization (SN) test. Post challenge viraemia was assessed in plasma. There was significant increase (P<0.05) in skin thickness in zinc adequated (ZnA) groups as compared to zinc deficient (ZnD) groups. The mean SN titre of ZnD groups was lower than the ZnA groups at all intervals. Mean virus titre was higher in ZnD groups as compared to ZnA groups at all intervals.

Keywords

Zinc deficiency, FMD, vaccination, immunity, guinea pigs