Comparative analysis of Nitric Oxide induction in blood mononuclear cells obtained from buffalo calves immunized with foot-and-mouth disease + haemorrhagic septicaemia combined vaccine or FMD alone vaccine

present study describes the comparative immunogenicity of FMD virus antigens in buffalo calves vaccinated either with combined FMD+HS vaccine or FMD alone vaccine. The immune response was monitored by nitric oxide production in peripheral blood mononuclear cell cultures. Considerably higher nitrous oxide production was observed in group of calves vaccinated with combined FMD+HS vaccine as compared to calves immunized with FMD alone vaccine with the difference being significant on 21 DPV in case of FMD virus types A and Asia 1.