Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, GB Pant University of Agriculture and Technology, Pantnagar-263145, (Uttaranchal), India.
Immunological response was assessed following single dermal spray of fenvalerate in buffalo calves. Nine, 5–6 months old healthy male buffalo calves were divided equally into three groups and were sprayed dermally with 0, 0.06 and 0.6 percent concentration of fenvalerate all over the body except the head region. Humoral immunity was assessed by determining haemagglutination titres (HA) against sheep red blood cells (SRBC). Delayed type hypersensitivity (DTH) was determined by measuring skin thickness (mm) against PPD for cellular immune response. A significant (P<0.01) reduction was observed in the HA titres against SRBC and skin thickness in the DTH response in fenvalerate treated calves as compared to control. It is concluded from the study that fenvalerate caused immunosuppression following its single dermal spray in 0.06 and 0.6% concentrations in buffalo calves.
Buffalo calves, Fenvalerate, Immunosuppression, Immunotoxicity, Synthetic pyrethroids
