G.N. Ramachandran Knowledge Centre for genome Informatics, Institute of Genomics and Integrative Biology (CSIR), Mall Road, Delhi, 110007, India. E-mail: ramu@igib.res.in; ramucbt@yahoo.com.
Pathogenic bacteria cause a wide variety of diseases in humans. Recently 133 bacterial genomes have been completely sequenced. A large number of these are pathogenic bacteria. The basic analysis of this genomic information has focussed on identifying the encoded genes, inferring the protein sequence and prediction of function using commonly used comparative sequence analysis. However, it was rapidly revealed that over 40% of proteins in any genome are refractory to this analysis. Therefore novel computational methods are required to obtain insights into the biological characteristics. We have been using compositional approach that has the potential to overcome the limits of sequence conservation and permits us to carry out comparative sequence analysis at larger evolutionary distances. We highlight the usefulness of our approach in the presentation.
