Department of Biological Sciences, University of Warwick, Coventry, UK
A mouse model for monitoring rotavirus virulence has been developed. Virulence was age dependent and dose dependent. Virulence was not restricted to a given serotype (s). The porcine OSU strain was found to be the most virulent of the strains used followed by bovine B223 and UKtc strains. Different host strains showed varying degrees of susceptibility to rotavirus induced disease. The CD-1 was found to be the most susceptible and C57/BL the least susceptible strain for infection with rotavirus.
rotavirus, mouse model, animal model, virulence
