Journal of Immunology and Immunopathology
  • Year: 2006
  • Volume: 8
  • Issue: 2

Trial of inactivated bluetongue vaccine in Bharat-Merino sheep

  • Author:
  • A.B. Pandey, S. Nandi, S.C. Dubey, G.G. Sonawane, B. Mondal, V. Bhanuprakash, S.D. Audarya, I. Suresh, K. Sharma, G. Prasad, R.K. Singh, N. Singh, R.S. Chauhan
  • Total Page Count: 2
  • Page Number: 145 to 146

All India Network Programme on Bluetongue, Centre for Animal Disease Research and Diagnosis, Indian Veterinary Research Institute, Izatnagar, Bareilly - 243 122 (Uttar Pradesh).

*E-mail: abpandey58@rediffmail.com

Abstract

A field trial of binary ethylenimine (BEI) inactivated saponified bluetongue virus-1 (BTV-1) vaccine was carried out in Bharat-Merino sheep at Central sheep and Wool Research Institute, Avikanagar. Vaccine elicited good group-specific and type specific antibody response, which persisted up to 7 months post vaccination. Haematological values remained within the safe range after vaccination. Animals were protected from virulent virus challenge by absence of clinical reaction and post challenge viraemia. However, a moderate to high inflammatory response at the site of inoculation warranted some modification in the vaccine/vaccination.

Keywords

Bluetongue, inactivated vaccine, BEI, saponin