Evaluation of Anti-hyperlipidemic activity of Hydroalcoholic extract of Ixora coccinea l. leaves on hyperlipidemic Wistar Albino Rats

This study was designed to evaluate the possible anti-hyperlipidemic and antioxidant effect of hydroalcoholic leaves extract of Ixora coccinea L. in triton (400 mg/kg, bw) and cafeteria diet induced hyperlipidemic rats. Hydroalcoholic leaves extract of Ixora coccinea was evaluated for antihyperlipidemic activity in tritonand cafeteria diet induced hyperlipidemic rats. Atorvastatin (10 mg/kg, bw) used as a standard drug for comparison. The results were expressed as mean± S.EM. and data was analyzed by using one way analysis of variance test (ANOVA) followed by Dunnett's t-test for multiple comparisons. Values with P < 0.05 were considered as significant. mg/kg) showed a significant (P< 0.05) reduction in the serum total cholesterol, triglyceride Treatment with Ixora coccinea (200 and 400 LDL-cholesterol and glucose level; and a significant (P< 0.05) increase in the serum HDL-cholesterol level in case of both models as compared to hyperlipidemic rats. Ixora coccinea leaves extract showed potential to moderate free radicals scavenging activity by reducing elevated MDA level in the liver, heart & serum and increasing in vivo antioxidant enzymes like CAT, SOD, GST, and GPx activities as compared to hyperlipidemic rats. The results demonstrated that hydroalcoholic extract of Ixora coccinea leaves has significant antihyperlipidemic activity and hence it could be exploited as an anti-hyperlipidemic therapeutic agent.