Formulation and Evaluation of Herbal Eye Gel from Heliotropium indium linn leaf extract for Conjunctivitis

Plants have played a significant role in maintaining human health and improving the quality of human life for thousands of years. The present work was designed with the aim to formulate and evaluate the ocular herbal gel containing Heliotropium indicum linn leaf extract. Cold infusion of the leaves used to remove cataract in the eye. The ocular herbal gel formulation was prepared from aqueous extract in varied concentration and was evaluated. The gel was formulated by using carbopol 934, EDTA, Benzalkonium chloride, and required amount of distilled water. Then the ocular pH 7.4 was maintained by drop wise addition of triethanolamine. The herbal ocular gels were sterilized and assessed for various parameters like clarity, pH, physical appearance, physical stability, viscosity, uniformity of drug content, spreadability and anti-microbial studies. Stability studies were carried out as per ICH guidelines for 6 months at different temperatures and humidity. The formulations in gel were found to be more stable at ambient, refrigerator and incubated temperature. The results showed that formulation glGL7 consisting aqueous leaf extract of Heliotropium indicum linn have better stability than other formulations.