Neurobehavioral assessments of Novel Pyrimidine derivative on experimental Zebra Fish

The present research is to explore the anti-anxiety property of novel synthesized pyrimidine derivative in zebra fish. We have investigated the anti-anxiety property of synthesized drug in different anti-anxiety model, trapezoid, light and dark and open field. LC50 value for drug was found as 5.5 mg/l. The dose are selected as in different concentration 1.1mg/l and 0.5mg/l. The Dive tank model was showing that fishes in test drug 1.1mg/L prefer to stay on the upper part of the trapezoidal tank, as well as the entry duration of the fish on the upper and middle part is also maximum as compare to lower part. Unfamiliar aquatic white/black maze environment model was showing that fishes in test drug 1.1mg/L prefer to stay in black zone and they are showing longer freezing time than other two groups. Open field treatment model was showing that fishes in test drug 1.1mg/L prefer to stay in inner zone and they are showing longer freezing time than other two groups. The overall result shows that the drug has anti-anxiety and sedation activity. Sedation activity is more prominent than anti-anxiety property.