Formulation and Evaluation of Phytosome Loaded Drug Delivery of Gingerol for the treatment of respiratory infection

Respiratory tract infection (RTI) is a well-known issues and influence the working of the lungs and other respiratory organs in winter season, especially in kids and adults. The phyto-constituent antibacterial drug [Gingerol] was used to treat RTI but it exhibits pharmacological issues. To overcome these issues and make home grown treatment more viably for the treatment of RTI, novel drug delivery (nanoparticle) based phytosome loaded complex approach was adopted.

The phytosome (GP) was prepared by mixing of gingerol and soya lecithin using anti-solvent precipitation technique. The phytosome loaded complex (LPC) was prepared by loading of phytosome (GLPC) in chitosan aqueous solution and characterized & evaluated by different parameters. The physical compatibility studies by DSC and FT-IR, demonstrated the confirmation of GLPC with soya lecithin and chitosan. The optimized GLPC and GP were irregular particle & spherical structures, with a mean particle size of 254.01±0.05 nm(−13.11 mV) and431.21±0.90nm (−17.53 mV), respectively.

The % entrapment efficiency and % drug loading of GLPC (86.02±0.18%, 08.26±0.72%) and GP (84.36±0.42%, 08.05±0.03%) was found, respectively. The in vitro release rate of GP (86.03±0.06%) was slower than GLPC (88.93±0.33%) in pH 7.4 phosphate buffer up to 24 h by diffusion process (Korsmeyer Peppas model). GLPC has shown the potent antioxidant activity, susceptible antibacterial activity and significant anti-inflammatory activity as compared to GP. GLPC has improved the significant bioavailability and also correlate the hematological values on rabbit blood against the incubation of microorganisms (S. aureus & E. coli). The prepared nanoparticle based complex of phytosome loaded of phyto-constituent drug has the combined effect of chitosan and phytosome which shown better sustained-release profile and also prolonging the oral absorption rate of gingerol with effective antibacterial activity in a better stable way at different storage conditions than phytosome or drug with chitosan.