Spectrophotometric determination of lamotrignine using oxidative coupling reaction in Pharmaceutical dosage forms.

A Simple, precise, accurate and sensitive extractive method has been developed for the quantitative estimation of lamotriginein bulk drugs and pharmaceutical formulations. The method is based on reaction of oxidative coupling of lamotrigine with 3-Methyl-2-Benzthiazolinone hydrochloride (MBTH) to form green colored product. Lamotrigine at its λmax 663 nm shows linearity in the concentration range of 2–8μg/ml. The relative standard deviations of 0.404% were obtained. Linear relationships with good correlation coefficients 0.999 were found between absorbance and the corresponding concentrations of the drug. The reliability and performance of the proposed methods was validated statistically the percentage recovery ranged from 96.6 and 105% respectively. The results of analysis for this method have been validated statistically and by recoverystudies.