Analysis of Leigh Disease with Seizures and Co-Morbid Metabolic Conditions Leigh Disease

Leigh disease is a relatively terrible disorder that is “neurometabolic” in nature and is found to occur in young children and new-borns. It is also sometimes called Juvenile Subacute Necrotizing Encephalopathy (JSNE). Leigh disease is an evolved/advanced disorder and it works by attacking the nervous system. It usually manifests in neonates and young children and it presents symptoms such as cough, cold, usual hallucinations, respiratory disorders, and difficulty in swallowing. Seizures is also a very common occurrence. Usually, it is known to manifest in children between 3 months-2 years. But infrequently it is seen in teenagers and adults. Leigh syndrome occurs as a result of a flaw in the general functioning of the mitochondrial DNA.

The central nervous system due to the absence of energy in the cells, triphosphate which occurs as a result of the obstruction of the action of the thiamine diphosphate kinase in the manifestation of Leigh disease. Alternative treatments involve the use of sodium citrate or sodium bicarbonate which has been found to help combat lactic acidosis. (Dichloroacetate is also considered albeit is still in the research phase). For metabolic disorders, diet is regulated, and in the causative event due to X-linked recessive inheritance, a low carbohydrate diet is highly advised.