Dept. of Pharmaceutics, NIMS Institute of Pharmacy, NIMS University, Jaipur, India
Online published on 27 September, 2019.
The antitumor activity of vinorelbine is may be due to primarily inhibition of mitosis during metaphase and its interaction with tubulin. The aqueous solubility of the drug is > 1000 mg/mL in distilled water. Prolonged vinorelbine exposure is correlated with improved antineoplastic effects, as evidenced by increased response rate in patients receiving continuous infusion. A phase I pharmacokinetic study of the Vinorelbine liposomal injection has been reported and concluded well toleratedand exhibited more favourable pharmacokinetic profiles than free vinorelbine. The Dendrimers are new class of artificial macromolecules. Dendrimer possess a well-defined topological structure, dendrimer through active targeting, and can be accumulated in tumours via the enhanced permeability and retention (EPR) effect of the nanosized dendrimer through passive targeting effect
Vinorelbine, Pamam dendrimer, Liposome, Cancer, Drug delivery system
