1Department of Pharmacy, Shri Jagdishprasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu - 333001, Rajasthan
2Department of Pharmacy, K. Govind Reddy Institute of Technology and Management, Rampally, Keesara, Hyderabad
*darshanamvijaykumar@gmail.com
Online published on 22 January, 2021.
The aim of the present study was to develop floating matrix formulation of Piretanide to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of natural polymers and celluloses were employed as polymers. Piretanide dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 25, 50 and 75 mg. All the formulations passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern 96.33 % in 12 hours. It followed zero order release kinetics mechanism.
Piretanide, Eudragit RL 100, Eudragit RS 100, Ethyl cellulose, Sustained release tablets
