Lead Acetate induced Histological alterations in Seminal-vesicle and Prostate Gland of Wistar rats

Lead (Pb), a heavy metal, is toxic to both human and animals. There is evidence in the literature that, lead is highly toxic metal for human and other mammals. The toxic effect of lead can manifest in various organs, and the male reproductive organ is an important target.

The objective of present study is to investigate the effect of lead acetate on seminal vesicle and prostate gland in Wistar rats. Eighteen adult Wistar rats were divided into three groups, A, B and C. Group A was control and provided with normal food and water as well as Group B and C were received 5mg/kg body weight of lead acetate daily for 15 and 30 days respectively. After the completion of treatment body and organs weight and histology of seminal vesicle and prostate gland were examined.

Results showed that decrease in body weight and organs weight when compared to control. Histopathology of seminal vesicle of treated rats showed, destruction in epithelial lining, reduction in mucosal fold of anddecrease in secretion as compared to control. As well as prostate gland of treated group shows lower secretary activity of epithelium, reduced secretion, flattening of epithelium lining and increasing interstitial space between alveoli.

It can be concluded from the results that lead acetate cause toxic effect on seminal vesicle, prostate gland and impaired male fertility.