Antinutrient composition and Effect of Ethanol Extract of Vernonia Amygdalina Stem on Serum Lipid Profile in monosodium Glutamate-Intoxicated rats

Vernonia amygdalina stem as food waste was assessed for antinutrients and its effect on serum lipid profile of monosodium glutamate-intoxicated rats. Twenty (20) adult male Wistar rats were randomly assigned into fve groups (A-E). Group A (control) rats were administered water only. Group B rats received 8000 mg/kg body weight monosodium glutamate (MSG). Group C rats received the sample extract while those in groups D and E received 8000 mg/kg body weight MSG plus 200 mg kg and 400 mg/kg boby weight extract, respectively. Antinutrients detected were: tannin (130.06 ± 11.67 mg/100 g), trypsin inhibitor (7.75 ± 0.02 µl/mg) and phytate (1.10 ± 0.01 mg/100 g). After 14 days exposure, triacylglycerol (TAG) concentration in the MSG-rat group was Significantly (p<0.05) higher as compared to tbat in the other rat groups except the group E rats. Tota cholesterol (TCHOL) and low-density lipoprotein (LDL) concentration in the MSG-treated rats were Significantly (p<0.05) higher than the corresponding parameters in the other rat groups. Rats in the MSG group had Significantly (p<0.05) lower high density lipoprotein (HDL) concentration compared to the low and high dose extract groups (D and E). Thus tannin is the most abundant out of the determined antinutrients in Vernonia amygdalina stem. And, the sample extract showed a Significant lipid lowering effect either alone or simultaneously with MSG-ntoxicaton. The apparently synergistc interactve effect of the sample extract with MSG-intoxication on the HDL concentration in the rats could be Significant hence warrants follow-up.