Cypermethrin-induced Histochemical Changes in Liver of Albino Rats

Cypermethrin is a synthetic pyrethroid insecticide that has high insecticidal activity, low avian and mammalian toxicity, and adequate stability in air and light.

This paper is an attempt to study its toxicity in vivo in rat liver at cellular level.

Following exposure to oral, sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose and multiple dose with 48 h interval, the histochemical changes were studied in different groups of rat livers. Histochemical examination indicated depletion of polysaccharides in the liver. This change occurred in a dose and timedependent manner in treated rat liver.