*Department of Pharmacology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi-110025
**Department of Pharmacology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal
1Corresponding Author E-mail: nk999999@rediffmail.com, Phone: +91-9868257149
Online published on 27 March, 2014.
Effect of Tianeptine (5-HT reuptake enhancer) was studied on the working memory deficits induced by scopolamine, amuscarinic receptor antagonist in rats using a three-panel runway apparatus. Scopolamine in the dose of 0.56 mg/kg, ip was administered alone or in combination with physostigmine (0.32 mg/kg) and tianeptine, in the doses of 5.0 mg/kg &15 mg/kg, ip and working memory errors and latency period of the session were recorded on a three-panel runway apparatus. Treatment with scopolamine (0.56 mg/kg) produced working memory deficits in rats. Treatment with tianeptine did not reverse or significantly aggravate the working memory impairment produced by scopolamine. Tianeptine alone in the dose of 15 mg/kg had no effect on the working memory.
Three-panel runway apparatus, Working Memory, Tianeptine, Scopolamine
