1MBBS, MD, Senior Resident, Department of Biochemistry, AIIMS, New Delhi, E-mail: drashoklhmc@gmail.com
2MBBS, MD, Assistant Professor, Department of Physiology, Pacific Institute of Medical Sciences, Udaipur, Rajasthan, E-mail: pankajkumar.keshri0@gmail.com
3MBBS, MD, Associate professor, Department of Physiology, Jhalawar Medical College, Jhalawar, Rajasthan, E-mail: shweta221277@yahoo.co.in
4MBBS, MD, Director Professor, Head of Department, Department of Biochemistry, LHMC, New Delhi, E-mail: dranjujain57@gmail.com
5MBBS, Chirayu Medical College and Hospital, Bhopal, Madhya Pradesh, E-mail: pradeepahirwar21@gmail.com
6MBBS, Junior Resident, Department of Pediatrics, NSCB Medical College and Hospital, Jabalpur, Madhya Pradesh, E-mail: dr.nishant1986@gmail.com
7MBBS, MD, Senior Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College & Hospital, AMU, Aligarh, Uttar Pradesh, E-mail: nehanehajain1986@gmail.com
8MBBS, MD, DNB, Associate Professor, Department of Biochemistry, LHMC, New Delhi, E-mail: binita.dr@gmail.com
9MBBS, MD, Director Professor, Department of Medicine, LHMC, New Delhi, E-mail: drmkbhatnagar@gmail.com
10MBBS, MD, Principal, VMMC, New Delhi, E-mail: jayashreedr@gmail.com
*Address of correspondence: Room no. 3013, Department of Biochemistry, Third Floor, Teaching Block, AIIMS, Ansari Nagar, New Delhi-110027, Phone no.: +91-9654210832
Online published on 30 December, 2015.
The metabolic syndrome (MS) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Insulin Resistance is the one of the main culprit involved in the pathogenesis of MS and its comorbidity like CVD and DM.
To study the insulin resistance among the study subjects.
We enrolled 50 diagnosed case of metabolic syndrome as per International Diabetes Federation (IDF) criteria and 50 healthy volunteers as control. Insulin resistance was assessed by measuring fasting serum Insulin levels, HOMA-IR.
The difference in the mean fasting blood glucose levels, post prandial blood sugar, HbA1c, serum Insulin and HOMA-IR between the study group(181.3 ± 70.9 mg/dl), (232.4 ± 94 mg/dl), (8.56 ± 2.73%), (14.6 ± 13μIU/ml), (6.4 ± 7.1) and control group (96.3 ± 7.5 mg/dl), (140.74 ± 142 mg/dl), (6.6 ± 3%), (6.6 ± 3μIU/ml), (1.62 ± 0.753) were significant with levels being higher in study group then that of controls.
Our study demonstrated that insulin resistance is involved in etiopathogenesis of Metabolic syndrome. This could be therapeutic target for the development of drug which could alleviate Insulin resistance and prevent the development of Metabolic syndrome, cardiovascular disease and diabetes mellitus. This would be beneficial for the prior identification of high risk individuals as well as for the monitoring of the disease status by assessing the insulin resistance and recommending to adopt the healthy life style.
Metabolic syndrome, Obesity, Insulin Resistance, HOMA-IR
