Molecular Genetics Laboratory, School of Biotechnology, National Institute of Technology, Calicut, Calicut-673601, Kerala, India
*Correspondence Address: Dr. M Anaul Kabir, Phone: +91-495-2285461; Fax: +91495-2287250; E-mail: anaulk@nitc.ac.in
Online published on 27 May, 2016.
S. cerevisiae, owing to its attractive features as a model organism, has become an integral part of biomedical research. It plays an important role in elucidating molecular mechanisms underlying several disease conditions like infections, carcinogenesis and neurodegeneration. The genetic and metabolic similarities yeasts share with human beings has enabled the researchers worldwide to make breakthrough discoveries, which, in turn, improved diagnosis and treatment.
Complementation analysis, heterologous expression of human proteins, humanization different approaches have converted simple ideas into elaborate experiments, uncovering elegant mechanisms. This review is an attempt to appreciate a few contributions that has been made to medicine, with the help of the simplest eukaryote which has simplified tasks for us from breweries to sophisticated laboratories.
Yeast, Disease model, Parasite biology, Cancer biology, Neurodegeneration
