Journal of Oral Medicine, Oral Surgery, Oral Pathology and Oral Radiology
  • Year: 2017
  • Volume: 3
  • Issue: 1

Synchronous squamous cell carcinoma of the lips: A literature review & case report

1Professor, Dept. of Oral & Maxillofacial Pathology, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka

2PG Student, Dept. of Oral & Maxillofacial Pathology, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka

3Associate Professor & Incharge, Dept. of Oral Medicine & Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi

*Corresponding Author: Email: drmandeepsandhu@gmail.com

Online published on 20 June, 2017.

Abstract

Oral cancer is the sixth most common cancer worldwide accounting for 2–4% of all cancer cases. Second primary tumors (SPT), are considered to be a poor prognostic indicator for overall survival. Synchronous tumors are the SPTs that occur simultaneously or within 6 months of the index tumor. Synchronous squamous cell carcinoma frequently occurs in oral cavity (39%) with incidence rates of the lip ranging from 10–18%. SPTs are usually aggressive in nature with early metastasis and therefore require more aggressive treatment. We report a rare case of synchronous oral squamous cell carcinoma occurred in a relatively young patient (< 40 years) involving both upper and lower lips with literature review focusing on the pathogenesis and various studies that reported synchronous Oral Squamous Cell Carcinomas of the lip.

Keywords

Squamous cell carcinoma, Second primary tumor, Synchronous tumor, Field cancerization, Patch theory, Vertical recruitment