Disseminated herpes simplex infection in a neonate

Herpes simplex virus (HSV) infection in a newborn is commonly due to HSV 2 and less commonly due to HSV 1.^1,2 Mixed HSV 1& 2 infection in newborn is rarely reported.³ Neonatal HSV infection can present as-a) Localized skin,eye and mouth (SEM) affection; b) Central nervous system (CNS) disease or c)Disseminated disease.^1,4,5

We report an unusual case of HSV infection in a neonate due both HSV 1& HSV 2. It led to initial manifestation just like septicemia and ultimately prolonged cholestasis that responded to acyclovir therapy.