Department of Dermatology and Venereology, Lady Hardinge Medical College, New Delhi, 110 001. E-mail: vibhumendiratta@rediffmail.com.
Blistering diseases in neonates could be primary due to either a genetic mutation or autoimmune response or they may be secondary to infections, local injury of the skin or passive transfer of maternal antibodies, resulting in fluid accumulation within a specific layer of the skin. Some diseases are characterized by self limiting lesions and are considered benign.