1Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka, India
2Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka, India
3Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka, India
4Department of Clinical Biochemistry, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
*Address for correspondence: Dr. Abhishek Singh, Postgraduate Student, Department of Oral Medicine & Radiology, Govt. Dental College and Research Institute, Bangalore, Karnataka, India. Email id: singhabhishek.rims@gmail.com
Online published on 3 February, 2012.
The aim of this study was to measure the concentration of serum total proteins and albumin as potent anti-oxidants, and advanced oxidation protein products as markers of oxidant mediated protein damage in the sera of patients diagnosed with oral cancers.
The study consisted of sera analysis of aforementioned parameters in 25, age and sex matched healthy adults and 30 patients with histologically proven oral cancers. Patients with other active disease processes and who were on other forms of therapeutic modalities were excluded from the study.
The study revealed variations in sera levels of albumin and advanced oxidation protein products to be statistically significant implying the diagnostic relevance of these biochemical markers in patients diagnosed with oral cancers.
The results obtained emphasize the need for more studies with larger sample sizes to be conducted in this regard before a conclusive role could be drawn in favor of the aforementioned biochemical markers as important diagnostic adjuncts in patients diagnosed with oral cancers.
Oral squamous cell carcinoma, oxidative, serum, total protein, advanced oxidation protein products (AOPP), albumin
