World Health Organization has clearly identified prevention and early detection as majorobjectives in the control of the oral cancer burden worldwide. At the present time, screening oforal cancer and precancerous lesions is still largelybased on visual examination of the mouth. Visualinspection of the oral mucosa may be effective in reducing mortality from oral cancer in individuals exposed to risk factors but visual examination is however limited bysubjective interpretation and by the potential of occurrence of dysplasia and early OSCCwithin areas of normal-looking oral mucosa. As a consequence, adjunctive techniques have been suggested to increase ability to differentiate between benign abnormalities and dysplastic/malignant changes as well as to identify areas of dysplasia/early OSCC that are not visible to nakedeye. These include the use of toluidine blue, brush biopsy, chemiluminescence and tissueautofluorescence.
Screening Tests, Brush Biopsy, Toluidine Blue, Chemiluminescence, VELscope
