A Comparative Study on Serum Lipid Profile in Pregnant Woman Suffering from Diabetes

The concept of present study is to find out the alterations in lipid profile in normal and diabetic patients during pregnancy. Four groups of subjects, Group A - healthy non-pregnant women without diabetes (Control), Group B - non-pregnant women with diabetes, Group C - pregnant women without diabetes and Group D - pregnant women with diabetes in the third trimester of pregnancy, were investigated for serum lipid profile. There was a significant increase in LDL and VLDL cholesterol levels and significant decrease in the HDL cholesterol level in pregnant subjects as compared to the diabetic non-pregnant subjects. However, no significant change was observed in total cholesterol and triglyceride during pregnancy in subjects as compared to the diabetic non-pregnant subjects. The maximum level of triglyceride, LDL and VLDL were observed in pregnant subjects suffering from diabetes. In our findings, the elevation of ratio of LDL/HDL and TG/HDL was also observed during pregnancy in diabetic as well as non-diabetic patients.