1Assistant Professor, Department of Oral & Maxillofacial Pathology, M. B. Kedia Dental College Pvt. Ltd., Birgunj, Nepal
2Assistant Professor, Department of Conservative Dentistry & Endodontics, M. B. Kedia Dental College Pvt. Ltd., Birgunj, Nepal
3Assistant Professor, Department of Oral & Maxillofacial Pathology, Genesis Institute of Dental Sciences & Research, Firozpur, Punjab, India
4Reader, Department of Orthodontics, D.J. College of Dental Sciences & Research, Modinagar, Uttar Pradesh, India
5Reader, Department of Prosthodontics, Genesis Institute of Dental Sciences & Research, Firozpur, Punjab, India
*Address for correspondence: Krishan Kumar Tyagi, Email id: krish621@gmail.com
Online published on 22 March, 2016.
The odontogenic cyst is derived from rest of dental lamina which shows a different growth mechanism and biological behaviour from the more common dentigerous and radicular cyst. The pathogenesis of syndrome associated and sporadic keratocystic odontogenic tumour (KCOT) involve a ‘two hit mechanism ’with allelic loss, which shows that the odontogenic cyst is not a cyst but a tumour.
Odontogenic keratocyst (OKC), Protein patched homolog (PTCH), Smoothened (SMO), Sonic hedgehog (SHH), Keratocystic odontogenic tumour (KCOT)
