1Department of Oral Medicine and Radiology, Dayananda Sagar College of Dental Sciences, Bangalore-78, Karnataka, India
2Department of Oral Medicine and Radiology, RV Dental College, Bangalore-78, Karnataka, India
*Correspondence Address: Dr. Chaya M David, MDS Professor and Head Department of Oral Medicine and Radiology, Dayananda Sagar College of Dental Sciences,. Shavige Malleswara Hills, Kumaraswamy Layout Bangalore 560078. chaya_alfred@yahoo.com Telephone 9844253310
This study was conducted to detect papillomavirus structural antigens in oral squamous cell carcinomas, and in normal oral tissues. The peroxidase-anti-peroxidase method, which is an immunohistochemical staining method was used. Out of the 35 oral carcinomas examined, seven (20%) were found to be positive, while none of the 26 normal oral tissue specimens examined were positive. This statistically significant finding further substantiated the role of human papillomavirus (HPV) in oral carcinogenesis. HPV is also found to be associated with precancerous states and cervical cancers.
Carcinogenesis, Oral squamous cell carcinoma, Human papilloma virus, Immunohistochemistry
