1Dept of Oral Medicine and Radiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India
2Dept of Oral Medicine & Radiology, College of Dental Science, Davangere, Karnataka, India
3Dept of Oral Medicine & Radiology, Bapuji Dental College, Davangere, Karnataka, India
4Dept of Oral Medicine & Radiology, College of Dental Science, Davangere, Karnataka, India
5Dept of Oral Medicine & Radiology, Bapuji Dental College, Davangere, Karnataka, India
*Corresponding Author: Dr. Shivakumar G.C. M.D.S. E-mail: shiva21375@yahoo.in
Online published on 12 June, 2012.
To detect the chemicals like arecoline and nicotine, in two commercial brands of gutkha and areca nut, and to relate such chemicals to functional and histological staging of oral submucous fibrosis.
The study group consisted of 50 subjects who were clinically and histologically diagnosed as oral submucous fibrosis. Three samples were taken into analysis, 1) Raw arecanut 2) 555 Star Gutkha & 3) Manikchand Pan Parag Gutkha.
The 50 subjects were in the age range of 12–57 years, 36 (72%) chewed only gutkha. Arecoline consumption per day ranged from 0.45 to 6.00 mg, and that of nicotine was 0.0 to 132.5 mg. Out of 25 subjects who consumed 1 to 2% of arecoline, 7, 5, 7 and 6 were in Group I, II, III and IV respectively. More number of subjects (15) consumed 31.0 to 40.0 mg of nicotine. Out of which 4, 2, 5 and 4 were in the Group of I, II, III and IV respectively.
The relationship between arecoline and nicotine consumption (per day) with functional and histopathological staging was not significant. Thus OSMF seem to be multifactorial origin.
oral submucous fibrosis, gutkha, arecoline, nicotine
